Kelch-Like ECH-Associated Protein 1 (KEAP1) Antibody
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
Kelch-Like ECH-Associated Protein 1 (KEAP1) Antibody is a Rabbit polyclonal antibody for the detection of Human Kelch-Like ECH-Associated Protein 1 (KEAP1).
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Kelch-Like ECH-Associated Protein 1 (KEAP1) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | 0.01 M PBS, pH 7.4, 50% glycerol, 0.05% Proclin-300. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q14145 |
| Gene ID | 9817 |
| NCBI Accession | NP_036421.2 |
| Background | Antibody anti-KEAP1 |
| Status | RUO |
Descripción
Related Products
Human KEAP1 (kelch-like ECH-associated protein 1) ELISA Kit
Ver Producto
KEAP1 antibody
This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene.
Ver ProductoKEAP1 antibody
Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome.
Ver Producto