Karyopherin Alpha 3 (KPNA3) Antibody
416€ (200 µl)
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935106861
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name
Karyopherin Alpha 3 (KPNA3) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx430368
tested applications
P-ELISA, WB, IHC
Description
KPNA3 Antibody is a Goat Polyclonal antibody against KPNA3.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Karyopherin Alpha 3 (KPNA3) |
| Host | Goat |
| Reactivity | Human |
| Recommended Dilution | P-ELISA: 1/128000, WB: 0.1-0.3 µg/ml, IHC: 6 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, WB, IHC |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 3839, 16648 |
| NCBI Accession | NP_002258.2 |
| Alias | QIP2,Importin alpha Q2,Importin subunit alpha-4,SRP1,SRP4,IPOA4,SPG88; Hsrp1,SRP1gamma |
| Background | Antibody anti-KPNA3 |
| Status | RUO |
| Note | Concentration: 0.5 mg/ml - |
Descripción
KPNA3, or importin-α3, is another member of the importin-α family that mediates the nuclear import of cargo proteins with classical nuclear localization signals (NLS). It interacts with importin-β to form a complex that transports cargo proteins through the nuclear pore complex (NPC). KPNA3 is expressed in various tissues and is particularly important in regulating nuclear transport during cell signaling, differentiation, and immune responses. It has roles in viral infections, where it mediates the nuclear import of viral proteins such as influenza and HIV components, aiding viral replication. Dysregulation of KPNA3 is associated with neurological disorders and cancer, where it influences nuclear transport of transcription factors and oncogenes. Knockout and functional studies show its essential role in maintaining cellular homeostasis and regulating nuclear import efficiency during development and stress responses.
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