Interleukin 7 Receptor (IL7R) Antibody

Este producto es parte de IL7R - interleukin 7 receptor
Product Graph
273€ (200 µl)

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935106861
info@markelab.com
name
Interleukin 7 Receptor (IL7R) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx430359
tested applications
P-ELISA, WB

Description

CD127 Antibody is a Goat Polyclonal antibody against CD127.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Interleukin 7 Receptor (IL7R)
Host
Goat
Reactivity
Mouse
Recommended Dilution
P-ELISA: 1/32000. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Size 1
200 µl
Form
Liquid
Tested Applications
P-ELISA, WB
Buffer
Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
Gene ID
16197, 294797
NCBI Accession
NP_032398.3
Alias
Interleukin-7 receptor subunit alpha,ILRA,CD127,IL7RA,CDW127,IMD104,sIL-7R,lnc-IL7R,IL7Ralpha,IL-7Ralpha,IL-7R-alpha,IL-7 receptor subunit alpha; IL-7R subunit alpha,IL-7RA
Background
Antibody anti-IL7R
Status
RUO
Note
Concentration: 0.5 mg/ml - 

Descripción

The interleukin-7 receptor (IL7R) is a critical component of immune system regulation, playing a major role in the development, survival, and homeostasis of T cells and, to a lesser extent, B cells. It is encoded by the IL7R gene and consists of two distinct subunits: IL-7Rα (CD127), which is unique to the IL-7 receptor, and γc (CD132), a common gamma chain shared with other cytokine receptors such as those for IL-2, IL-4, IL-9, IL-15, and IL-21. IL-7, the ligand for IL7R, is an essential cytokine that provides survival signals to developing lymphocytes and regulates their function, influencing T cell diversity, immune tolerance, and immune responsiveness. The IL7R signaling pathway has profound effects on immune system homeostasis, enabling it to counteract immune deficiencies, support immune recovery after depletion, and maintain immune memory. Dysregulation of IL7R, however, is implicated in a range of conditions, including severe combined immunodeficiency (SCID), autoimmune diseases, and certain cancers, especially T-cell acute lymphoblastic leukemia. The receptor’s pivotal role in lymphocyte biology makes it a significant target for immunological therapies and interventions.

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