Interleukin 5 Receptor alpha (IL5RA) Antibody
637€ (100 µl)
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Name
Interleukin 5 Receptor alpha (IL5RA) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx113255
Tested Applications
ELISA, WB, IHC
Description
Interleukin 5 Receptor, Alpha Antibody is a Rabbit Polyclonal antibody against Interleukin 5 Receptor, Alpha.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Interleukin 5 Receptor alpha (IL5RA) Immunogen: Human IL5RA. |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.3, containing 0.1% Sodium Azide and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q01344 |
| Gene ID | 3568 |
| NCBI Accession | NP_000555.2, NM_000564.4 |
| OMIM | 147851 |
| Alias | IL5R,CD125,CDw125,HSIL5R3,IL-5 receptor subunit alpha,IL-5R subunit alpha,IL-5R-alpha,IL-5RA |
| Background | Antibody anti-IL5RA |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Interleukin-5 receptor subunit alpha (IL5RA) is a protein critical for mediating immune responses involving eosinophils. Encoded by the IL5RA gene, this receptor forms a part of the IL-5 receptor complex, which is primarily responsible for binding interleukin-5 (IL-5), a cytokine crucial in regulating the growth, differentiation, and activation of eosinophils and basophils. Eosinophils, in particular, are involved in immune responses against parasitic infections and play a role in allergic inflammation and diseases such as asthma and eosinophilic esophagitis. IL-5, along with its receptor IL5RA, is also implicated in the development and maintenance of T-helper 2 (Th2)-mediated immune responses, which play a role in allergic diseases. By engaging IL5RA on eosinophils and other cells, IL-5 signaling promotes survival, activation, and accumulation of these cells at inflammatory sites. Due to its central role in driving eosinophil-mediated inflammation, IL5RA is a target for therapeutic interventions, especially in asthma, chronic rhinosinusitis with nasal polyps, and hypereosinophilic syndrome.
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