Interleukin 37 (IL37) Antibody

Este producto es parte de IL37 - Interleukin 37
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247€ (100 µl)

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935106861
info@markelab.com
name
Interleukin 37 (IL37) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx131959
tested applications
WB, IHC, IF/ICC

Description

Interleukin 1 Zeta Antibody is a Mouse Monoclonal against Interleukin 1 Zeta.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Interleukin 37 (IL37)
Host
Mouse
Reactivity
Human
Recommended Dilution
WB: 0.01-5 µg/ml, IHC: 5-30 µg/ml, IF/ICC: 5-30 µg/ml. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Monoclonal
Conjugation
Unconjugated
Isotype
IgG2b Kappa
Clone ID
C401
Purification
Purified by Protein A and Protein G affinity chromatography.
Size 1
100 µl
Size 2
200 µl
Size 3
1 ml
Form
Liquid
Tested Applications
WB, IHC, IF/ICC
Buffer
0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol.
Availability
Shipped within 5-7 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
Q9NZH6
Alias
IL-37,IL37,IL-1F7, IL-1F7, IL-1H, IL-23
Background
Antibody anti-IL37
Status
RUO

Descripción

IL37 is a unique member of the IL-1 family that functions as an anti-inflammatory cytokine by suppressing immune activation and limiting excessive inflammation. IL37 is synthesized as a precursor that translocates to the nucleus or binds to the IL-18 receptor alpha chain (IL18Rα) and IL1R8 (SIGIRR), leading to inhibition of NF-κB, MAPK, and inflammatory cytokine production. It is expressed in epithelial cells, monocytes, and dendritic cells, particularly during inflammatory and infectious conditions. IL37 acts as a master suppressor of inflammation by reducing pro-inflammatory cytokine levels, chemokine production, and immune cell activation. It plays a protective role in autoimmune diseases, cardiovascular diseases, and metabolic disorders, where its overexpression reduces inflammation and tissue damage. Dysregulation of IL37 is linked to chronic inflammatory diseases such as rheumatoid arthritis, lupus, and colitis. Knockdown studies demonstrate exacerbated inflammation, increased cytokine production, and tissue pathology, highlighting IL37's role as a crucial anti-inflammatory mediator and immune regulator in maintaining tissue homeostasis and controlling immune responses.

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