Interleukin 36 Gamma / IL1F9 (IL36G) Antibody

Este producto es parte de IL36G - Interleukin-36 gamma
Interleukin 36 Gamma / IL1F9 (IL36G) Antibody

Pida mas información

935106861

info@markelab.com

Precio

312€ (100 µl)

Antibody anti-IL36G

proveedor

Abbexa

reference

abx131960

Tested Applications

WB, IHC, IF/ICC

reactivity

Mouse

status

RUO

clonality

Monoclonal

Descripción

Interleukin 1 Family, Member 9 Antibody is a Mouse Monoclonal against Interleukin 1 Family, Member 9.


Background

IL36G, another member of the IL-1 family, functions as a potent pro-inflammatory cytokine by signaling through the IL-36 receptor (IL1RL2) and IL1RAP, leading to activation of NF-κB, ERK, and MAPK pathways. IL36G is highly expressed in epithelial cells, particularly in the skin, lungs, and gastrointestinal tract, where it acts as an amplifier of local inflammation. It induces the production of cytokines, chemokines, and antimicrobial peptides, enhancing the recruitment of immune cells like T cells, dendritic cells, and neutrophils to barrier tissues during infection, injury, or inflammatory insults. IL36G plays a critical role in psoriasis pathogenesis, where it triggers keratinocyte proliferation and immune cell infiltration, contributing to chronic inflammation and skin remodeling. Dysregulated IL36G expression is also associated with respiratory diseases and inflammatory bowel disease. Knockdown studies show impaired immune cell recruitment and weakened epithelial responses, highlighting IL36G's role as an inflammation driver, immune amplifier, and barrier tissue regulator.

Características del producto

category

Primary Antibodies


clonality

Monoclonal


reactivity

Mouse


immunogen target

Interleukin 36 Gamma / IL1F9 (IL36G)


host

Mouse


isotype

IgG2a Kappa


conjugation

Unconjugated


form

Liquid


tested applications

WB, IHC, IF/ICC


purification

Purified by Protein A and Protein G affinity chromatography.


recommended dilution

WB: 0.5-3 µg/ml, IHC: 5-30 µg/ml, IF/ICC: 5-30 µg/ml. Optimal dilutions/concentrations should be determined by the end user.


buffer

PBS, pH 7.4, containing 0.02% sodium azide, 50% glycerol.


size 1

100 µl


size 2

200 µl


size 3

1 ml


storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.


or code

IL36G


dry ice

No


availability

Shipped within 5-7 working days.


alias

IL1F9, IL-36γ, IL36γ,IL-36 gamma,IL36 gamma,IL-36g,IL36g,IL36G,IL-36G,IL-1F9


note

Concentration: 1 mg/ml -


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