Interleukin 23 (IL23A) Antibody

Product specifications

Primary Antibodies

Interleukin 23 (IL23A)

Mouse

Human

WB: 1/500 - 1/2000, IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user.

Monoclonal

Unconjugated

IgG1

≥ 95% (SDS-PAGE)

Purified by Protein A and Protein G affinity chromatography.

100 µg

Liquid

ELISA, WB, IHC

PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.

Shipped within 5-12 working days.

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

No

Q9NPF7

P19,SGRF,IL-23,L-23A,IL23P19,L-23 subunit alpha,IL-23-A,Interleukin-23 subunit p19 IL-23p19

Antibody anti-IL23A

RUO

Concentration: 2 mg/ml - Validity: 12 months.

Descripción

Interleukin 23A (IL23A), also referred to as IL-23, is a heterodimeric cytokine that plays a pivotal role in immune regulation, inflammation, and host defense. It is a member of the IL-12 cytokine family, which is integral to bridging the innate and adaptive immune systems. IL-23 is predominantly produced by antigen-presenting cells (such as dendritic cells and macrophages) and acts mainly on T cells, specifically promoting the differentiation, expansion, and maintenance of Th17 cells. IL-23 is essential for chronic inflammation and has been implicated in several autoimmune and inflammatory diseases, including psoriasis, rheumatoid arthritis (RA), Crohn’s disease, and multiple sclerosis (MS). Unlike its close relative IL-12, which promotes Th1 responses and interferon-γ (IFN-γ) production, IL-23 plays a critical role in the IL-23/Th17 axis, influencing the production of IL-17 and other pro-inflammatory cytokines that contribute to tissue inflammation

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