Interleukin 2 Receptor Beta (IL2RB) Antibody (APC)

Este producto es parte de IL2RB - interleukin 2 receptor subunit beta
Product Graph
429€ (100 tests)

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935106861
info@markelab.com
name
Interleukin 2 Receptor Beta (IL2RB) Antibody (APC)
category
Primary Antibodies
provider
Abbexa
reference
abx140446
tested applications
FCM

Description

CD122 Antibody (APC) is a Mouse Monoclonal antibody conjugated to APC against CD122.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Interleukin 2 Receptor Beta (IL2RB)
Host
Mouse
Reactivity
Human
Recommended Dilution
FCM: 10 µl/100 µl of whole blood or 106 cells. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Monoclonal
Conjugation
APC
Isotype
IgG1 Kappa
Clone ID
S942
Purification
Purified by protein-A affinity chromatography from tissue culture supernatant. The conjugate is purified by size-exclusion chromatography.
Size 1
100 tests
Tested Applications
FCM
Buffer
Stabilizing PBS solution containing 15 mM sodium azide.
Availability
Shipped within 5-12 working days.
Storage
Store in the dark at 2-8°C. Avoid exposure to light. Do not freeze.
Dry Ice
No
UniProt ID
P14784
Gene ID
3560
Alias
CD122,IMD63,IL15RB,P70-75,High affinity IL-2 receptor subunit beta,Interleukin-15 receptor subunit beta
Background
Antibody anti-IL2RB
Status
RUO

Descripción

IL2RB, or interleukin-2 receptor beta subunit, is a crucial component of the interleukin-2 (IL-2) receptor complex. The IL-2 receptor is vital for T cell activation, proliferation, and survival and is central to immune responses. IL2RB, specifically, is essential for transmitting signals that control the growth, differentiation, and survival of T cells. The IL-2 receptor complex consists of three subunits: the IL-2 receptor alpha (IL2RA or CD25), IL-2 receptor beta (IL2RB or CD122), and IL-2 receptor gamma (IL2RG or CD132). Together, these subunits form a high-affinity receptor for IL-2 that is primarily expressed on activated T cells, natural killer (NK) cells, and other immune cell types. IL2RB, encoded by the IL2RB gene on chromosome 22q12.3, is a key signaling subunit. It binds IL-2 with intermediate affinity independently but, when combined with IL2RG, forms the high-affinity IL-2 receptor that effectively transmits intracellular signals upon IL-2 binding. IL2RB plays a significant role in immune homeostasis and regulation, influencing T cell differentiation, NK cell development, and peripheral tolerance. Dysregulation of IL2RB expression or function is linked to various immune disorders, including autoimmune diseases, immunodeficiencies, and certain cancers.

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