Interleukin 2 Receptor Beta (IL2RB) Antibody (APC)

429€ (100 tests)
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935106861
info@markelab.com
name
Interleukin 2 Receptor Beta (IL2RB) Antibody (APC)
category
Primary Antibodies
provider
Abbexa
reference
abx140446
tested applications
FCM
Description
CD122 Antibody (APC) is a Mouse Monoclonal antibody conjugated to APC against CD122.
Documents del producto
Instrucciones
Data sheet
Product specifications
Category | Primary Antibodies |
Immunogen Target | Interleukin 2 Receptor Beta (IL2RB) |
Host | Mouse |
Reactivity | Human |
Recommended Dilution | FCM: 10 µl/100 µl of whole blood or 106 cells. Optimal dilutions/concentrations should be determined by the end user. |
Clonality | Monoclonal |
Conjugation | APC |
Isotype | IgG1 Kappa |
Clone ID | S942 |
Purification | Purified by protein-A affinity chromatography from tissue culture supernatant. The conjugate is purified by size-exclusion chromatography. |
Size 1 | 100 tests |
Tested Applications | FCM |
Buffer | Stabilizing PBS solution containing 15 mM sodium azide. |
Availability | Shipped within 5-12 working days. |
Storage | Store in the dark at 2-8°C. Avoid exposure to light. Do not freeze. |
Dry Ice | No |
UniProt ID | P14784 |
Gene ID | 3560 |
Alias | CD122,IMD63,IL15RB,P70-75,High affinity IL-2 receptor subunit beta,Interleukin-15 receptor subunit beta |
Background | Antibody anti-IL2RB |
Status | RUO |
Descripción
IL2RB, or interleukin-2 receptor beta subunit, is a crucial component of the interleukin-2 (IL-2) receptor complex. The IL-2 receptor is vital for T cell activation, proliferation, and survival and is central to immune responses. IL2RB, specifically, is essential for transmitting signals that control the growth, differentiation, and survival of T cells. The IL-2 receptor complex consists of three subunits: the IL-2 receptor alpha (IL2RA or CD25), IL-2 receptor beta (IL2RB or CD122), and IL-2 receptor gamma (IL2RG or CD132). Together, these subunits form a high-affinity receptor for IL-2 that is primarily expressed on activated T cells, natural killer (NK) cells, and other immune cell types. IL2RB, encoded by the IL2RB gene on chromosome 22q12.3, is a key signaling subunit. It binds IL-2 with intermediate affinity independently but, when combined with IL2RG, forms the high-affinity IL-2 receptor that effectively transmits intracellular signals upon IL-2 binding. IL2RB plays a significant role in immune homeostasis and regulation, influencing T cell differentiation, NK cell development, and peripheral tolerance. Dysregulation of IL2RB expression or function is linked to various immune disorders, including autoimmune diseases, immunodeficiencies, and certain cancers.
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