Interleukin 2 Receptor Alpha (IL2RA) Antibody (AF647)
208€ (50 tests)
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Name
Interleukin 2 Receptor Alpha (IL2RA) Antibody (AF647)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx228897
Tested Applications
FCM
Description
CD25 antibody (AF647) is a Rat monoclonal antibody against CD25.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Interleukin 2 Receptor Alpha (IL2RA) |
| Host | Rat |
| Reactivity | Mouse |
| Detection Method | Laser Line: 647 Excitation/Emission: 651/666 |
| Clonality | Monoclonal |
| Conjugation | AF647 |
| Isotype | IgG1 |
| Size 1 | 50 tests |
| Size 2 | 25 µg |
| Size 3 | 100 tests |
| Size 4 | 100 µg |
| Size 5 | 200 tests |
| Tested Applications | FCM |
| Buffer | PBS with 0.05% Proclin300, 1% BSA. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at 2°C to 8°C upon receipt. Avoid exposure to light. Do not freeze. |
| Dry Ice | No |
| UniProt ID | P01590 |
| Gene ID | 16184 |
| Alias | p55,CD25,IL2R,IMD41,TCGFR,IDDM10,Interleukin-2 receptor subunit alpha,IL-2 receptor subunit alpha; IL-2-RA; IL-2R subunit alpha; IL2-RA,TAC antigen |
| Background | Antibody anti-IL2RA |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Interleukin 2 receptor subunit alpha (IL2RA), also known as CD25, is a crucial component of the high-affinity interleukin-2 (IL-2) receptor complex, which is essential for regulating immune responses, particularly T-cell proliferation and survival. The IL-2 receptor plays a pivotal role in both adaptive immunity and immune tolerance, with IL2RA being one of the three subunits that form the IL-2 receptor complex. The IL-2 receptor system is critically involved in the regulation of T-cell homeostasis, immune activation, and the suppression of autoimmunity. IL2RA is primarily expressed on activated T cells, particularly regulatory T cells (Tregs), which are crucial for maintaining immune tolerance. It is also found on other immune cells, including activated B cells, dendritic cells, and natural killer (NK) cells under certain conditions. Importantly, IL2RA expression is tightly regulated, being upregulated upon T-cell activation and playing a central role in fine-tuning immune responses.
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