Interleukin 17D (IL17D) Antibody
292.5€ (80 µl)
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935106861
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name
Interleukin 17D (IL17D) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx028222
tested applications
ELISA, WB
Description
The protein encoded by this gene is a cytokine that shares the sequence similarity with IL17. The treatment of endothelial cells with this cytokine has been shown to stimulate the production of other cytokines including IL6, IL8 and CSF2/ GM-CSF. The increased expression of IL8 induced by this cytokine was found to be NF-kappa B-dependent.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Interleukin 17D (IL17D) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q8TAD2 |
| Alias | IL-17D,Interleukin-27,IL27,IL-27 |
| Background | Antibody anti-IL17D |
| Status | RUO |
Descripción
Interleukin 17D (IL17D) is a member of the IL-17 cytokine family, which plays a crucial role in modulating the immune response, particularly in inflammation and host defense. The IL-17 family consists of six cytokines (IL-17A through IL-17F), all of which are involved in regulating immune responses, especially those associated with infection, autoimmunity, and tissue inflammation. IL-17D is one of the less well-characterized members of this family, but it is known to have distinct roles in the regulation of innate immunity, particularly in the induction of inflammatory cytokines in various tissues. Unlike the more widely studied IL-17A and IL-17F, which are produced by Th17 cells and have well-established roles in inflammatory diseases, the function of IL-17D has only recently come to light. It is expressed in a variety of non-hematopoietic cells, including fibroblasts, endothelial cells, and smooth muscle cells, where it acts to modulate immune responses by inducing the production of inflammatory cytokines and recruiting immune cells
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