Interleukin 17A (IL17A) Antibody (APC)

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935106861

info@markelab.com

Precio

Precio a consultar

proveedor

Abbexa

reference

abx229443

Tested Applications

FCM

reactivity

mouse

status

RUO

clonality

monoclonal

Descripción

IL-17A Antibody (APC) is a Mouse Monoclonal Antibody against IL-17A.

Background

The Interleukin 17 family is a group of pro-inflammatory cystine knot cytokines primarily produced by T helper 17 cells in response to stimulation with IL-23. IL17A, was previously known in rodents as CTLA8. In humans, The IL-17 family includes IL17A (sometimes referred to as "IL-17"), IL17B, IL17C, IL17D, IL17E (also known as IL-25), and IL17F. One of the most prominent roles of IL-17 is its participation in initiating and mediating proinflammatory responses. IL-17 is commonly associated with allergic reactions and can induce the production of various other cytokines (such as IL-6, G-CSF, GM-CSF, IL-1β, TGF-β, TNF-α), chemokines (including IL-8, GRO-α, and MCP-1), and prostaglandins (e.g., PGE2) from different cell types, including fibroblasts, endothelial cells, epithelial cells, keratinocytes, and macrophages


La familia interleucina 17 es un grupo de citocinas proinflamatorias del nudo de cistina ( 3 S_S ), producidas principalmente por células T Helper 17 en respuesta a la estimulación con IL-23. IL17A, se conocía anteriormente en roedores como CTLA8. En humanos, la familia IL-17 incluye IL17A (a veces denominada "IL-17"), IL17B, IL17C, IL17D, IL17E (también conocida como IL-25) e IL17F. Una de las funciones más destacadas de la IL-17 es su participación en el inicio y la mediación de respuestas proinflamatorias. La IL-17 se asocia comúnmente con reacciones alérgicas y puede inducir la producción de otras citoquinas (como IL-6, G-CSF, GM-CSF, IL-1β, TGF-β, TNF-α), quimiocinas (incluida IL -8, GRO-α y MCP-1) y prostaglandinas (p. ej., PGE2) de diferentes tipos de células, incluidos fibroblastos, células endoteliales, células epiteliales, queratinocitos y macrófagos.

Características del producto

immunogen target

Interleukin 17A (IL17A)


category

Primary Antibodies


size 1

20 tests


host

Rat


clonality

monoclonal


conjugation

APC


storage

Aliquot and store at 2°C to 8°C upon receipt. Avoid exposure to light. Do not freeze.


uniprot id

Q62386


gene id

16171


buffer

PBS with 0.05% Proclin300, 1% BSA.


assay data

Excitation/Emission: 651/660Laser line: 647


availability

Shipped within 5-15 working days


note

This product is for research use only.


isotype

IgG1 Kappa


status

RUO


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