Interleukin 17A (IL17A) Antibody

Pida mas información

935106861

info@markelab.com

Precio

175€ (20 µl)

proveedor

Abbexa

reference

abx000823

Tested Applications

reactivity

Human

status

RUO

clonality

Polyclonal

Descripción

IL17A Antibody is a Rabbit Polyclonal antibody against IL17A. The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.

Background

The Interleukin 17 family is a group of pro-inflammatory cystine knot cytokines primarily produced by T helper 17 cells in response to stimulation with IL-23. IL17A, was previously known in rodents as CTLA8. In humans, The IL-17 family includes IL17A (sometimes referred to as "IL-17"), IL17B, IL17C, IL17D, IL17E (also known as IL-25), and IL17F. One of the most prominent roles of IL-17 is its participation in initiating and mediating proinflammatory responses. IL-17 is commonly associated with allergic reactions and can induce the production of various other cytokines (such as IL-6, G-CSF, GM-CSF, IL-1β, TGF-β, TNF-α), chemokines (including IL-8, GRO-α, and MCP-1), and prostaglandins (e.g., PGE2) from different cell types, including fibroblasts, endothelial cells, epithelial cells, keratinocytes, and macrophages

Background

La familia interleucina 17 es un grupo de citocinas proinflamatorias del nudo de cistina ( 3 S_S ), producidas principalmente por células T Helper 17 en respuesta a la estimulación con IL-23. IL17A, se conocía anteriormente en roedores como CTLA8. En humanos, la familia IL-17 incluye IL17A (a veces denominada "IL-17"), IL17B, IL17C, IL17D, IL17E (también conocida como IL-25) e IL17F. Una de las funciones más destacadas de la IL-17 es su participación en el inicio y la mediación de respuestas proinflamatorias. La IL-17 se asocia comúnmente con reacciones alérgicas y puede inducir la producción de otras citoquinas (como IL-6, G-CSF, GM-CSF, IL-1β, TGF-β, TNF-α), quimiocinas (incluida IL -8, GRO-α y MCP-1) y prostaglandinas (p. ej., PGE2) de diferentes tipos de células, incluidos fibroblastos, células endoteliales, células epiteliales, queratinocitos y macrófagos.

Características del producto

clonality

Polyclonal

reactivity

Human

immunogen target

Interleukin 17A (IL17A)

host

Rabbit

conjugation

Unconjugated

form

Liquid

tested applications

purification

Purified by affinity chromatography.

buffer

PBS, pH 7.3, containing 0.05% Proclin-300, 50% glycerol.

size 1

20 µl

size 2

50 µl

size 3

100 µl

size 4

200 µl

storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

or code

IL17A

dry ice

availability

Shipped within 5-10 working days.

alias

IL17,CTLA8,IL-1,ILA17,CTLA-8,IL-17A

uniprot id

https://www.uniprot.org/uniprotkb/Q16552

gene id

https://www.ncbi.nlm.nih.gov/gene/3605

NCBI accession

NP_002181.1

note

This product is for research use only.

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