Interleukin 15 Receptor Subunit Alpha (IL15RA) Antibody
292.5€ (80 µl)
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935106861
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name
Interleukin 15 Receptor Subunit Alpha (IL15RA) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx030582
tested applications
ELISA, WB
Description
This gene encodes a cytokine receptor that specifically binds interleukin 15 (IL15) with high affinity. The receptors of IL15 and IL2 share two subunits, IL2R beta and IL2R gamma. This forms the basis of many overlapping biological activities of IL15 and IL2. The protein encoded by this gene is structurally related to IL2R alpha, an additional IL2-specific alpha subunit necessary for high affinity IL2 binding. Unlike IL2RA, IL15RA is capable of binding IL15 with high affinity independent of other subunits, which suggests distinct roles between IL15 and IL2. This receptor is reported to enhance cell proliferation and expression of apoptosis inhibitor BCL2L1/BCL2-XL and BCL2. Multiple alternatively spliced transcript variants of this gene have been reported.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Interleukin 15 Receptor Subunit Alpha (IL15RA) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified through a protein A column, followed by peptide affinity purification. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q13261 |
| Alias | IL-15 receptor subunit alpha,CD215,IL-15R-alpha |
| Background | Antibody anti-IL15RA |
| Status | RUO |
Descripción
Interleukin-15 receptor subunit alpha (IL15RA) is a receptor that binds to the cytokine interleukin-15 (IL-15), a protein central to immune system regulation, particularly in the development, activation, and survival of natural killer (NK) cells and memory CD8+ T cells. IL-15 plays a significant role in the immune response against viral infections and tumors and in sustaining long-lived immune memory. Unlike many other cytokine receptors, IL15RA binds IL-15 with very high affinity even without the presence of other receptor subunits, making it essential for IL-15’s function. This interaction is critical in immune homeostasis and is relevant in inflammation, cancer immunology, and autoimmune disease contexts.
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