Interleukin 15 Receptor Alpha (IL15RA) Antibody

Background

Interleukin-15 receptor subunit alpha (IL15RA) is a receptor that binds to the cytokine interleukin-15 (IL-15), a protein central to immune system regulation, particularly in the development, activation, and survival of natural killer (NK) cells and memory CD8+ T cells. IL-15 plays a significant role in the immune response against viral infections and tumors and in sustaining long-lived immune memory. Unlike many other cytokine receptors, IL15RA binds IL-15 with very high affinity even without the presence of other receptor subunits, making it essential for IL-15’s function. This interaction is critical in immune homeostasis and is relevant in inflammation, cancer immunology, and autoimmune disease contexts.