Interleukin 12B (IL12B) Antibody
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Description
Rabbit Polyclonal against the IL-12B protein.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Interleukin 12B (IL12B) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, IHC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by antigen affinity column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, IHC |
| Buffer | Prior to lyophilization: 1% BSA and 0.02% NaN3. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| NCBI Accession | NM_002187.2 |
| Alias | CLMF,NKSF,CLMF2,IMD28,IMD29,NKSF2,IL-12B,Cytotoxic lymphocyte maturation factor 40 kDa subunit,CLMF p40,IL-12 subunit p40,NK cell stimulatory factor chain 2 |
| Background | Antibody anti-IL12B |
| Status | RUO |
| Note | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. - |
Descripción
Interleukin 12 beta (IL12B), also referred to as IL-12p40, is another key subunit of interleukin-12 and is critical for immune regulation and pathogen defense. IL12B pairs with IL12A to form IL-12 or with IL23A to form IL-23, a related cytokine involved in promoting inflammation and autoimmunity. Produced primarily by antigen-presenting cells in response to microbial infections or inflammatory stimuli, IL12B drives the differentiation of naïve CD4+ T-cells into Th1 cells, promoting IFN-γ secretion and enhancing immune responses against intracellular pathogens. Genetic variations in IL12B have been linked to increased susceptibility to autoimmune disorders, such as psoriasis and inflammatory bowel disease (IBD). As a result, IL12B is a target of therapeutic interest in immune-mediated diseases, and IL-12/IL-23 inhibitors have been developed to treat conditions like psoriasis and Crohn's disease. Understanding the intricate regulation and functional roles of IL12B remains a priority in immunological research.
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