Interleukin 12B (IL12B) Antibody
637€ (100 µl)
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Name
Interleukin 12B (IL12B) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx113236
Tested Applications
ELISA, WB
Description
Interleukin 12B (Natural Killer Cell Stimulatory Factor 2, Cytotoxic Lymphocyte MatuRation Factor 2, P40) Antibody is a Rabbit Polyclonal antibody against Interleukin 12B (Natural Killer Cell Stimulatory Factor 2, Cytotoxic Lymphocyte MatuRation Factor 2, P40).
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Interleukin 12B (IL12B) Immunogen: Human IL12B. |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, containing 0.02% Sodium Azide and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P29460 |
| Gene ID | 3593 |
| OMIM | 161561 |
| Alias | CLMF,NKSF,CLMF2,IMD28,IMD29,NKSF2,IL-12B,Cytotoxic lymphocyte maturation factor 40 kDa subunit,CLMF p40,IL-12 subunit p40,NK cell stimulatory factor chain 2 |
| Background | Antibody anti-IL12B |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Interleukin 12 beta (IL12B), also referred to as IL-12p40, is another key subunit of interleukin-12 and is critical for immune regulation and pathogen defense. IL12B pairs with IL12A to form IL-12 or with IL23A to form IL-23, a related cytokine involved in promoting inflammation and autoimmunity. Produced primarily by antigen-presenting cells in response to microbial infections or inflammatory stimuli, IL12B drives the differentiation of naïve CD4+ T-cells into Th1 cells, promoting IFN-γ secretion and enhancing immune responses against intracellular pathogens. Genetic variations in IL12B have been linked to increased susceptibility to autoimmune disorders, such as psoriasis and inflammatory bowel disease (IBD). As a result, IL12B is a target of therapeutic interest in immune-mediated diseases, and IL-12/IL-23 inhibitors have been developed to treat conditions like psoriasis and Crohn's disease. Understanding the intricate regulation and functional roles of IL12B remains a priority in immunological research.