Interleukin 12 Phospho-35 (IL12 p35) Antibody
1040€ (10 mg)
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Name
Interleukin 12 Phospho-35 (IL12 p35) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx342105
Tested Applications
ELISA
Description
Interleukin 12 Phospho-35 (IL12 p35) Antibody is a sheep polyclonal antibody for the detection of Interleukin 12 Phospho-35.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Interleukin 12 Phospho-35 Immunogen: Recombinant Human IL12p35 |
| Host | Sheep |
| Reactivity | General |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Immunoglobulin fraction isolated by caprylic acid and ammonia sulphate precipitation. |
| Size 1 | 10 mg |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 20 mM Phosphate, 150 mM NaCl, pH 7.2, containing 0.09% Sodium azide. |
| Availability | Shipped within 10-20 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze-thaw cycles. |
| Dry Ice | No |
| Alias | P35,CLMF,NFSK,NKSF1,IL-12A,Cytotoxic lymphocyte maturation factor 35 kDa subunit,CLMF p35,IL-12 subunit p35,NK cell stimulatory factor chain 1 |
| Background | Antibody anti-IL12A |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Interleukin 12A (IL12A) is a subunit of the heterodimeric cytokine interleukin-12, which plays a pivotal role in the immune system by bridging innate and adaptive immunity. IL12A, also known as IL-12p35, pairs with the IL12B subunit (IL-12p40) to form the active cytokine IL-12, which is essential for inducing T-helper 1 (Th1) immune responses. IL12A is produced by activated antigen-presenting cells, such as macrophages and dendritic cells, in response to infections or immune challenges. It functions by stimulating natural killer (NK) cells and CD4+ T-cells to produce interferon-gamma (IFN-γ), a cytokine critical for pathogen clearance and enhancing cytotoxic activities. Dysregulation of IL12A expression has been associated with autoimmune diseases, chronic inflammation, and cancer. Therapeutic strategies targeting IL12A, including IL-12 inhibitors or engineered cytokines, are being explored for managing these conditions and for enhancing anti-tumor immune responses.
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