Interleukin 12 p40 (IL12 p40) Antibody
598€ (500 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Interleukin 12 p40 (IL12 p40) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx413222
tested applications
ELISA, IHC
Description
Interleukin 12 p40 (IL12 p40) Antibody is a Mouse Monoclonal antibody against Interleukin 12 p40 (IL12 p40).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Interleukin 12 p40 (IL12 p40) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | Validated in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Purification | Purified |
| Size 1 | 500 µg |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS. Contains sodium azide. |
| Availability | Shipped within 3-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P29460 |
| Alias | P35,CLMF,NFSK,NKSF1,IL-12A,Cytotoxic lymphocyte maturation factor 35 kDa subunit,CLMF p35,IL-12 subunit p35,NK cell stimulatory factor chain 1 |
| Background | Antibody anti-IL12A |
| Status | RUO |
| Note | Concentration: 1.0 mg/ml - |
Descripción
Interleukin 12A (IL12A) is a subunit of the heterodimeric cytokine interleukin-12, which plays a pivotal role in the immune system by bridging innate and adaptive immunity. IL12A, also known as IL-12p35, pairs with the IL12B subunit (IL-12p40) to form the active cytokine IL-12, which is essential for inducing T-helper 1 (Th1) immune responses. IL12A is produced by activated antigen-presenting cells, such as macrophages and dendritic cells, in response to infections or immune challenges. It functions by stimulating natural killer (NK) cells and CD4+ T-cells to produce interferon-gamma (IFN-γ), a cytokine critical for pathogen clearance and enhancing cytotoxic activities. Dysregulation of IL12A expression has been associated with autoimmune diseases, chronic inflammation, and cancer. Therapeutic strategies targeting IL12A, including IL-12 inhibitors or engineered cytokines, are being explored for managing these conditions and for enhancing anti-tumor immune responses.
Related Products
Human HS-IL-12 p70 (High sensitive Interleukin 12 p70) high sensitive Accquant ELISA Kit
Ver Producto
Bovine IL-12A (Interleukin-12 subunit alpha) ELISA Kit
Ver Producto