Interleukin 12 (IL12) Antibody (Biotin)
637€ (50 µg)
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935106861
info@markelab.com
name
Interleukin 12 (IL12) Antibody (Biotin)
category
Primary Antibodies
provider
Abbexa
reference
abx411702
tested applications
ELISA, WB
Description
Interleukin 12 (IL12) Antibody (Biotin) is a Goat Polyclonal antibody against Interleukin 12 (IL12).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Interleukin 12 (IL12) |
| Host | Goat |
| Reactivity | Mouse |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Biotin |
| Isotype | IgG |
| Purification | Purified |
| Size 1 | 50 µg |
| Form | Lyophilized |
| Tested Applications | ELISA, WB |
| Buffer | PBS. |
| Availability | Shipped within 3-7 working days. |
| Storage | Store lyophilized at 2°C to 8°C. After reconstitution, aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P43431, P43432 |
| Alias | P35,CLMF,NFSK,NKSF1,IL-12A,Cytotoxic lymphocyte maturation factor 35 kDa subunit,CLMF p35,IL-12 subunit p35,NK cell stimulatory factor chain 1 |
| Background | Antibody anti-IL12A |
| Status | RUO |
Descripción
Interleukin 12A (IL12A) is a subunit of the heterodimeric cytokine interleukin-12, which plays a pivotal role in the immune system by bridging innate and adaptive immunity. IL12A, also known as IL-12p35, pairs with the IL12B subunit (IL-12p40) to form the active cytokine IL-12, which is essential for inducing T-helper 1 (Th1) immune responses. IL12A is produced by activated antigen-presenting cells, such as macrophages and dendritic cells, in response to infections or immune challenges. It functions by stimulating natural killer (NK) cells and CD4+ T-cells to produce interferon-gamma (IFN-γ), a cytokine critical for pathogen clearance and enhancing cytotoxic activities. Dysregulation of IL12A expression has been associated with autoimmune diseases, chronic inflammation, and cancer. Therapeutic strategies targeting IL12A, including IL-12 inhibitors or engineered cytokines, are being explored for managing these conditions and for enhancing anti-tumor immune responses.
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