Interleukin 1 Receptor Type II (IL1R2) Antibody
442€ (200 µl)
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name
Interleukin 1 Receptor Type II (IL1R2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx432862
tested applications
P-ELISA, WB, IF/ICC, FCM
Description
IL1R2 Antibody is a Goat Polyclonal antibody against IL1R2.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Interleukin 1 Receptor Type II (IL1R2) Immunogen: abx616279 - Internal region: C-QYNITRSIELRIKK |
| Host | Goat |
| Reactivity | Human |
| Assay Type | Concentration: 0.5 mg/ml |
| Recommended Dilution | P-ELISA: 1/16000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, WB, IF/ICC, FCM |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 7850 |
| NCBI Accession | NP_004624.1, NP_001248348.1 |
| Alias | IL1R2,CD121d. IL1 RII |
| Background | Antibody anti-IL1R2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
IL1R2 functions as a decoy receptor for interleukin-1, competitively binding to IL-1α, IL-1β, and the IL-1 receptor accessory protein (IL1RAP) without initiating downstream signaling IL1R2 lacks an active intracellular signaling domain, thereby preventing activation of NF-κB and other pro-inflammatory pathways IL1R2 is expressed on the surface of monocytes, macrophages, and B cells, and it is also secreted in a soluble form (sIL1R2), which further neutralizes IL-1 activity in the extracellular environment By acting as a negative regulator of IL-1 signaling, IL1R2 plays an anti-inflammatory role and contributes to the resolution of immune responses IL1R2 expression is upregulated by anti-inflammatory cytokines such as IL-4 and IL-10, highlighting its role in immune regulation Dysregulation of IL1R2 is associated with inflammatory diseases, including sepsis, arthritis, and chronic autoimmune disorders, where its expression may serve as a biomarker for disease activity IL1R2’s ability to limit IL-1 activity makes it a critical target for therapeutic strategies aimed at reducing excessive inflammation and immune activation
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