Interleukin 1 Receptor Type I (IL1R1) Antibody (Biotin)

Este producto es parte de IL1R - Interleukin 1 Receptor Type
Product Graph
351€ (200 µl)

Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.

935106861
info@markelab.com
name
Interleukin 1 Receptor Type I (IL1R1) Antibody (Biotin)
category
Primary Antibodies
provider
Abbexa
reference
abx271908
tested applications
WB, IHC, IF/ICC

Description

Interleukin 1 Receptor Type I (IL1R1) Antibody (Biotin) is a Rabbit Polyclonal antibody conjugated to Biotin against Interleukin 1 Receptor Type I (IL1R1).

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Interleukin 1 Receptor Type I (IL1R1)
Host
Rabbit
Reactivity
Human
Recommended Dilution
WB: 0.5-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Biotin
Isotype
IgG
Purification
Purified by antigen-specific affinity chromatography.
Size 1
200 µl
Size 2
1 ml
Form
Liquid
Tested Applications
WB, IHC, IF/ICC
Buffer
0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol.
Availability
Shipped within 5-15 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
Alias
IL1R1,CD121a, IL1 RI
Background
Antibody anti-IL1R1
Status
RUO

Descripción

IL1R1 is a transmembrane receptor that belongs to the interleukin-1 receptor family and plays a central role in mediating pro-inflammatory signaling IL1R1 binds to interleukin-1α (IL-1α), interleukin-1β (IL-1β), and the IL-1 receptor antagonist (IL-1Ra), forming a receptor complex with the IL-1 receptor accessory protein (IL1RAP) to initiate downstream signaling Upon ligand binding, IL1R1 activates intracellular pathways such as nuclear factor kappa B (NF-κB) and mitogen-activated protein kinases (MAPKs), leading to the expression of pro-inflammatory cytokines, chemokines, and adhesion molecules IL1R1 is expressed on various immune and non-immune cells, including macrophages, fibroblasts, and epithelial cells, where it mediates immune responses to infection, injury, and inflammation Dysregulation of IL1R1 signaling is implicated in chronic inflammatory diseases such as rheumatoid arthritis, inflammatory bowel disease, and systemic lupus erythematosus IL1R1 is also a target for anti-inflammatory therapies, including drugs like anakinra, which block IL-1 binding to reduce inflammation and disease progression

Related Products

EH0186

Human IL1R1(Interleukin 1 Receptor Type I) ELISA Kit

Ver Producto
EM1160

Mouse IL-1R1(Interleukin 1 Receptor Type I) ELISA Kit

Ver Producto
Pr22491

Recombinant Mouse IL-1R1

Ver Producto