Interferon Gamma Receptor 1 (IFNGR1) Antibody
221€ (50 µg)
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Name
Interferon Gamma Receptor 1 (IFNGR1) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx330075
Tested Applications
ELISA, WB, IHC, IF/ICC
Description
IFNGR1 Antibody is a Rabbit Polyclonal against IFNGR1.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Interferon Gamma Receptor 1 (IFNGR1) Immunogen: Synthesized peptide derived from human IFN-γRα around the non-phosphorylation site of Y457. |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat, Monkey |
| Recommended Dilution | ELISA: 1/40000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/300, IF/ICC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IF/ICC |
| Buffer | PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P15260 |
| Gene ID | 3459 |
| Alias | IFN-gamma receptor 1,IFN-gamma-R1,CD119,IFNGR,IMD27A,IMD27B,CDw119,Interferon gamma receptor alpha-chain |
| Background | Antibody anti-IFNGR1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Interferon Gamma Receptor 1 (IFNGR1) is a pivotal transmembrane protein that serves as the primary receptor for interferon-gamma (IFN-γ), a crucial cytokine involved in innate and adaptive immune responses. IFNGR1 is predominantly expressed on the surface of immune cells, such as macrophages, T lymphocytes, and natural killer (NK) cells, and also on various non-immune cell types. Structurally, IFNGR1 is composed of an extracellular domain that binds IFN-γ, a transmembrane region, and a cytoplasmic tail that interacts with downstream signaling components. Upon IFN-γ binding, IFNGR1 forms a functional receptor complex with IFNGR2, initiating the JAK-STAT signaling cascade. This pathway leads to the activation of STAT1, which translocates to the nucleus to regulate the transcription of genes involved in antimicrobial defense, antigen presentation, and immune cell differentiation. Genetic mutations or deficiencies in IFNGR1 can result in immunodeficiencies, such as Mendelian susceptibility to mycobacterial diseases (MSMD), characterized by impaired responses to intracellular pathogens like mycobacteria and certain viruses. Due to its central role in immune regulation, IFNGR1 is extensively studied in the context of infectious diseases, autoimmunity, and cancer immunotherapy, where modulating its activity could enhance immune responses or mitigate pathological inflammation.
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