Integrin Beta III / CD61 (ITGB3) Antibody
780€ (1 ml)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Integrin Beta III / CD61 (ITGB3) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx172964
tested applications
WB, IHC, IF/ICC
Description
This product is currently in development. The lead time for this product may be several months. Please contact us at
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Integrin Beta III / CD61 (ITGB3) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Purification | Purified by Protein A and Protein G affinity chromatography. |
| Size 1 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Please enquire. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | GT,GT2,CD61,GP3A,BDPLT2,GPIIIa,BDPLT16,BDPLT24,Integrin beta-3,Platelet membrane glycoprotein IIIa |
| Background | Antibody anti-ITGB3 |
| Status | RUO |
Descripción
ITGB3 (Integrin Subunit Beta 3) encodes the β3 subunit of integrins, which are transmembrane receptors that mediate cell-cell and cell-extracellular matrix (ECM) interactions. Integrins are essential in diverse cellular processes, including cell adhesion, migration, signal transduction, immune responses, and angiogenesis. The ITGB3 protein partners with αIIb (encoded by ITGA2B) and αV (encoded by ITGAV) to form αIIbβ3 and αVβ3 integrins, respectively. These heterodimers are pivotal for platelet aggregation, thrombosis, wound healing, and interactions with extracellular matrix proteins like fibrinogen, fibronectin, and vitronectin. ITGB3 is expressed in platelets, endothelial cells, and various tissues involved in cell movement and immune responses. Dysregulation or mutation of ITGB3 can lead to disorders such as Glanzmann thrombasthenia, affecting platelet function, or it can play a role in pathological conditions like cancer metastasis, where altered cell adhesion and migration are key.
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The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling.
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