Integrin Beta 4 (ITGb4) Antibody
383.5€ (100 µl)
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name
Integrin Beta 4 (ITGb4) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx015900
tested applications
ELISA, WB, IHC, FCM
Description
Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors.Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities.Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth.This gene encodes the integrin beta 4 subunit, a receptor for the laminins.This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma.Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia.Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Integrin Beta 4 (ITGb4) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Purification | Unpurified ascites. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, FCM |
| Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P16144 |
| Gene ID | 3691 |
| OMIM | 131800 |
| Alias | Integrin beta-4,CD104,GP150,JEB5A,JEB5B |
| Background | Antibody anti-ITGB4 |
| Status | RUO |
Descripción
Integrin subunit beta 4 (ITGB4) is a vital cell-adhesion molecule in the integrin family, specifically expressed in epithelial cells, where it plays a critical role in cell adhesion, signal transduction, and cellular responses to external stimuli. ITGB4 is notable for its involvement in forming hemidesmosomes, specialized structures that attach epithelial cells to the basement membrane, thereby contributing to tissue integrity, resilience, and structural stability. ITGB4 often pairs with the alpha 6 integrin subunit (forming the α6β4 integrin complex), allowing these integrins to specifically interact with laminins in the extracellular matrix. These interactions mediate a variety of essential biological processes, including cell adhesion, migration, differentiation, and survival. Due to its essential role in maintaining epithelial tissue structure and regulating cellular signaling, dysregulation or mutations in ITGB4 have been associated with a range of disorders, including epidermolysis bullosa and certain cancers.
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