Integrin Beta 4 (ITGb4) Antibody

Product specifications

Primary Antibodies

Integrin Beta 4 (ITGb4)

Mouse

Human

Validated in IHC-F. Optimal dilutions/concentrations should be determined by the end user.

Monoclonal

Unconjugated

IgG1

Purified

1 mg

Liquid

WB, IHC, IF/ICC, FCM, IP

Normal saline

Shipped within 3-7 working days.

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

No

P16144

Integrin beta-4,CD104,GP150,JEB5A,JEB5B

Antibody anti-ITGB4

RUO

Concentration: 1.0 mg/ml -

Descripción

Integrin subunit beta 4 (ITGB4) is a vital cell-adhesion molecule in the integrin family, specifically expressed in epithelial cells, where it plays a critical role in cell adhesion, signal transduction, and cellular responses to external stimuli. ITGB4 is notable for its involvement in forming hemidesmosomes, specialized structures that attach epithelial cells to the basement membrane, thereby contributing to tissue integrity, resilience, and structural stability. ITGB4 often pairs with the alpha 6 integrin subunit (forming the α6β4 integrin complex), allowing these integrins to specifically interact with laminins in the extracellular matrix. These interactions mediate a variety of essential biological processes, including cell adhesion, migration, differentiation, and survival. Due to its essential role in maintaining epithelial tissue structure and regulating cellular signaling, dysregulation or mutations in ITGB4 have been associated with a range of disorders, including epidermolysis bullosa and certain cancers.

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