Integrin Beta 4 (ITGb4) Antibody
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
Integrin Beta-4 (CD104) Antibody is a Mouse Monoclonal antibody against Integrin Beta-4 (CD104).
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Integrin Beta 4 (ITGb4) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | Validated in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Purification | Purified |
| Size 1 | 25 µg |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC, FCM, IP |
| Buffer | PBS. Contains sodium azide. |
| Availability | Shipped within 3-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P16144 |
| Alias | Integrin beta-4,CD104,GP150,JEB5A,JEB5B |
| Background | Antibody anti-ITGB4 |
| Status | RUO |
| Note | Concentration: 1.0 mg/ml - |
Descripción
Integrin subunit beta 4 (ITGB4) is a vital cell-adhesion molecule in the integrin family, specifically expressed in epithelial cells, where it plays a critical role in cell adhesion, signal transduction, and cellular responses to external stimuli. ITGB4 is notable for its involvement in forming hemidesmosomes, specialized structures that attach epithelial cells to the basement membrane, thereby contributing to tissue integrity, resilience, and structural stability. ITGB4 often pairs with the alpha 6 integrin subunit (forming the α6β4 integrin complex), allowing these integrins to specifically interact with laminins in the extracellular matrix. These interactions mediate a variety of essential biological processes, including cell adhesion, migration, differentiation, and survival. Due to its essential role in maintaining epithelial tissue structure and regulating cellular signaling, dysregulation or mutations in ITGB4 have been associated with a range of disorders, including epidermolysis bullosa and certain cancers.
Related Products
Recombinant Human CD104
Ver Producto
Integrin Beta 4 (ITGb4) Antibody
ITGB4 Antibody is a Rabbit Polyclonal antibody against ITGB4. Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Ver Producto
ITGB4 (Phospho-Tyr1510) Antibody
Rabbit polyclonal antibody against ITGB4 protein. Immunogen region is C-terminal. Specificity is as follows for the reactive species: H:Y1510, M:Y1318, R:Y1441.
Ver Producto