Integrin Beta 2 (ITGB2) Antibody
507€ (200 µg)
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Name
Integrin Beta 2 (ITGB2) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx414996
Tested Applications
IHC, IF/ICC, FCM, IP
Description
Integrin Beta-2 (CD18) Antibody is a Rat Monoclonal antibody against Integrin Beta-2 (CD18).
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Integrin Beta 2 (ITGB2) |
| Host | Rat |
| Reactivity | Human |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | Validated in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG2b |
| Purification | Purified |
| Size 1 | 200 µg |
| Form | Liquid |
| Tested Applications | IHC, IF/ICC, FCM, IP |
| Buffer | PBS. Contains sodium azide. |
| Availability | Shipped within 3-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P05107 |
| Alias | LAD,CD18,MF17,MFI7,LCAMB,LFA-1,MAC-1,Integrin beta-2,Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta,Complement receptor C3 subunit beta |
| Background | Antibody anti-ITGB2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
ITGB2, or integrin subunit beta 2, is a protein that plays a central role in leukocyte adhesion and signaling, facilitating the immune system's response to infections and inflammation. ITGB2, also known as CD18, is part of the integrin family, which consists of transmembrane receptors involved in cell-cell and cell-extracellular matrix (ECM) interactions. Integrins are heterodimeric proteins formed by the association of alpha (α) and beta (β) subunits. In particular, ITGB2 pairs with various alpha integrin subunits to form key receptors known as beta-2 integrins. Beta-2 integrins are primarily expressed on leukocytes (white blood cells) and are essential for mediating cell adhesion, migration, phagocytosis, and immune surveillance. The four major integrins that involve ITGB2 are LFA-1 (αLβ2, CD11a/CD18), Mac-1 (αMβ2, CD11b/CD18), gp150/95 (αXβ2, CD11c/CD18), and αDβ2 (CD11d/CD18). These integrins are vital for the immune system's ability to respond to infections and regulate inflammation.
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