Leukocyte Surface Antigen CD47 (CD47) Antibody
312€ (0.1 mg)
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935106861
info@markelab.com
name
Leukocyte Surface Antigen CD47 (CD47) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx139289
tested applications
WB, IHC, FCM
Description
CD47 Antibody is a Mouse Monoclonal against CD47.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Leukocyte Surface Antigen CD47 (CD47) |
| Host | Mouse |
| Reactivity | Human, Pig, Monkey |
| Recommended Dilution | FCM: 1-4 μg/ml. WB validated in non-reducing conditions. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgM |
| Clone ID | Z974 |
| Purity | > 95% (SDS-PAGE) |
| Purification | Purified from ascites by precipitation and chromatography. |
| Size 1 | 0.1 mg |
| Tested Applications | WB, IHC, FCM |
| Buffer | TBS solution with 15 mM sodium azide. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store at 2-8°C. Do not freeze. |
| Dry Ice | No |
| UniProt ID | Q08722 |
| Gene ID | 961 |
| OMIM | 601028 |
| Alias | IAP,OA3,MER6,Antigenic surface determinant protein OA3,Integrin-associated protein, |
| Background | Antibody anti-CD47 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
CD47, also known as integrin-associated protein (IAP), is a widely expressed transmembrane glycoprotein that plays a critical role in immune regulation, cell signaling, and cellular adhesion. It is a member of the immunoglobulin superfamily and is involved in numerous biological processes, including immune evasion, apoptosis, angiogenesis, and cell migration. One of CD47's primary functions is to act as a "don't eat me" signal to prevent macrophage-mediated phagocytosis, which is a key component in the immune system's ability to clear dead cells and pathogens. CD47 interacts with signal regulatory protein alpha (SIRPα), a receptor primarily expressed on myeloid cells, such as macrophages and dendritic cells. The binding of CD47 to SIRPα sends an inhibitory signal to macrophages, preventing the phagocytosis of CD47-expressing cells. This interaction plays a critical role in protecting normal cells from immune clearance but can also be exploited by cancer cells to evade immune detection and destruction.
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