Leukocyte Surface Antigen CD47 (CD47) Antibody
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935106861
info@markelab.com
Precio
337.5€ (100 µg)
Antibody anti-CD47
proveedor
Abbexareference
abx122743Tested Applications
ELISA, IHCreactivity
Humanstatus
RUOclonality
PolyclonalDescripción
Rabbit Polyclonal against the CD47 protein.
Background
CD47, also known as integrin-associated protein (IAP), is a widely expressed transmembrane glycoprotein that plays a critical role in immune regulation, cell signaling, and cellular adhesion. It is a member of the immunoglobulin superfamily and is involved in numerous biological processes, including immune evasion, apoptosis, angiogenesis, and cell migration. One of CD47's primary functions is to act as a "don't eat me" signal to prevent macrophage-mediated phagocytosis, which is a key component in the immune system's ability to clear dead cells and pathogens. CD47 interacts with signal regulatory protein alpha (SIRPα), a receptor primarily expressed on myeloid cells, such as macrophages and dendritic cells. The binding of CD47 to SIRPα sends an inhibitory signal to macrophages, preventing the phagocytosis of CD47-expressing cells. This interaction plays a critical role in protecting normal cells from immune clearance but can also be exploited by cancer cells to evade immune detection and destruction.
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Human
immunogen target
Leukocyte Surface Antigen CD47 (CD47)
host
Rabbit
conjugation
Unconjugated
form
Lyophilized
tested applications
ELISA, IHC
purification
Purified by antigen affinity column chromatography.
buffer
Prior to lyophilization: 1% BSA and 0.02% NaN3.
size 1
100 µg
storage
Store at -20 °C. Avoid repeated freeze/thaw cycles.
or code
CD47
dry ice
No
availability
Shipped within 7-15 working days.
alias
IAP,OA3,MER6,Antigenic surface determinant protein OA3,Integrin-associated protein,
uniprot id
note
This product is for research use only.
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