Integrin alpha-V / Integrin Beta-3 (ITGAV/ITGB3) Antibody
312€ (0.1 mg)
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935106861
info@markelab.com
name
Integrin alpha-V / Integrin Beta-3 (ITGAV/ITGB3) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx140635
tested applications
IHC, FCM, IP
Description
Integrin alpha-V / Integrin Beta-3 (ITGAV / ITGB3) Antibody is a mouse monoclonal antibody against Integrin alpha-V / Integrin Beta-3 (ITGAV / ITGB3).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Integrin alpha-V / Integrin Beta-3 (ITGAV / ITGB3) |
| Host | Mouse |
| Reactivity | Human, Chicken |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Clone ID | F616 |
| Purification | Purified by Protein A affinity chromatography. |
| Size 1 | 0.1 mg |
| Tested Applications | IHC, FCM, IP |
| Buffer | PBS solution with 15 mM sodium azide. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store at 2-8°C. Do not freeze. |
| Dry Ice | No |
| Alias | CD51,MSK8,VNRA,VTNR,Integrin alpha-V,Vitronectin receptor,Vitronectin receptor subunit alpha |
| Background | Antibody anti-ITGAV |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
Integrin subunit alpha V (ITGAV) is a crucial component of the integrin family, a group of transmembrane receptors involved in cell-cell and cell-extracellular matrix (ECM) interactions. Integrins are heterodimeric proteins composed of alpha (α) and beta (β) subunits that, when combined, form receptors with various functions, primarily in cell adhesion, migration, proliferation, and signal transduction. ITGAV plays a particularly important role in binding to multiple ligands, including vitronectin, fibronectin, osteopontin, and components of the ECM, enabling it to mediate diverse biological processes such as angiogenesis, tissue repair, immune responses, and tumorigenesis. The gene encoding integrin alpha V (ITGAV) is located on chromosome 2q31.1 in humans. ITGAV pairs with several beta subunits (particularly β1, β3, β5, β6, and β8) to form distinct integrin heterodimers, each with unique ligand specificity and biological function. The most well-characterized integrins involving ITGAV are αvβ3, αvβ5, αvβ6, and αvβ8, which play significant roles in processes like wound healing, angiogenesis, and tumor progression.
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