Integrin Alpha-L (ITGAL) Antibody
299€ (0.1 mg)
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935106861
info@markelab.com
name
Integrin Alpha-L (ITGAL) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx139605
tested applications
FCM, IP, FUNC
Description
CD11a Antibody is a Mouse Monoclonal against CD11a.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Integrin Alpha-L (ITGAL) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Clone ID | C874 |
| Purity | > 95% (SDS-PAGE) |
| Purification | Purified by Protein A affinity chromatography. |
| Size 1 | 0.1 mg |
| Tested Applications | FCM, IP, FUNC |
| Buffer | LE/AF PBS solution, 0.2 µm filter sterilized. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store at 2-8°C. Do not freeze. |
| Dry Ice | No |
| UniProt ID | P20701 |
| Gene ID | 3683 |
| Alias | CD11A,LFA-1,LFA1A,CD11 antigen-like family member A,Leukocyte adhesion glycoprotein LFA-1 alpha chain,LFA-1A,Leukocyte function-associated molecule 1 alpha chain |
| Background | Antibody anti-ITGAL |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
Integrin subunit alpha L (ITGAL), also known as CD11a, is a protein encoded by the ITGAL gene in humans. This protein forms a part of the integrin family, which is a group of cell surface receptors that mediate various biological processes, including immune cell adhesion, migration, and signaling. ITGAL pairs with the integrin beta-2 subunit (CD18) to form the LFA-1 (lymphocyte function-associated antigen 1), a heterodimeric receptor crucial for immune responses. ITGAL’s primary role is in the immune system, where it facilitates cell-cell adhesion during the immune response, helping lymphocytes, neutrophils, and other leukocytes adhere to other cells, such as endothelial cells, antigen-presenting cells, and target cells. This integrin is particularly critical in the homing, trafficking, and activation of immune cells, including T cells, natural killer (NK) cells, and neutrophils. ITGAL mediates interactions between leukocytes and the vascular endothelium by binding to intercellular adhesion molecules (ICAMs), which are vital for immune surveillance and the body's response to infection and inflammation.
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