Integrin Alpha-L (ITGAL) Antibody
260€ (50 µl)
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Name
Integrin Alpha-L (ITGAL) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx339187
Tested Applications
ELISA, IHC
Description
ITGAL Antibody is a Rabbit Polyclonal against ITGAL.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Integrin Alpha-L (ITGAL) Immunogen: Synthetic peptide of human ITGAL. |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/1000 - 1/2000, IHC: 1/15 - 1/50. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P20701 |
| Gene ID | 3683 |
| Alias | CD11A,LFA-1,LFA1A,CD11 antigen-like family member A,Leukocyte adhesion glycoprotein LFA-1 alpha chain,LFA-1A,Leukocyte function-associated molecule 1 alpha chain |
| Background | Antibody anti-ITGAL |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Integrin subunit alpha L (ITGAL), also known as CD11a, is a protein encoded by the ITGAL gene in humans. This protein forms a part of the integrin family, which is a group of cell surface receptors that mediate various biological processes, including immune cell adhesion, migration, and signaling. ITGAL pairs with the integrin beta-2 subunit (CD18) to form the LFA-1 (lymphocyte function-associated antigen 1), a heterodimeric receptor crucial for immune responses. ITGAL’s primary role is in the immune system, where it facilitates cell-cell adhesion during the immune response, helping lymphocytes, neutrophils, and other leukocytes adhere to other cells, such as endothelial cells, antigen-presenting cells, and target cells. This integrin is particularly critical in the homing, trafficking, and activation of immune cells, including T cells, natural killer (NK) cells, and neutrophils. ITGAL mediates interactions between leukocytes and the vascular endothelium by binding to intercellular adhesion molecules (ICAMs), which are vital for immune surveillance and the body's response to infection and inflammation.
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