Integrin Alpha IIb / CD41 (ITGA2B) Antibody (PE)
338€ (0.1 mg)
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Name
Integrin Alpha IIb / CD41 (ITGA2B) Antibody (PE)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx140063
Tested Applications
FCM
Description
CD41 Antibody is a Rat Monoclonal against CD41.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Integrin Alpha IIb / CD41 (ITGA2B) Immunogen: Murine platelets. |
| Host | Rat |
| Reactivity | Mouse |
| Detection Method | Laser Line: 550 Excitation/Emission: 565/575 |
| Assay Type | Concentration: 0.5 mg/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | PE |
| Isotype | IgG1 Kappa |
| Clone ID | Z929 |
| Size 1 | 0.1 mg |
| Tested Applications | FCM |
| Buffer | PBS solution with 15 mM sodium azide. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store in the dark at 2-8°C. Avoid exposure to light. Do not freeze. |
| Dry Ice | No |
| UniProt ID | Q9QUM0 |
| Gene ID | 16399 |
| Alias | GT,GT1,GTA,CD41,GP2B,HPA3,CD41B,GPIIb,BDPLT2,BDPLT16,PPP1R93,Integrin alpha-Iib,GPalpha IIb (GPIIb),Platelet membrane glycoprotein IIb |
| Background | Antibody anti-ITGA2B |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
ITGA2B, also known as integrin alpha 2b or CD41, is a transmembrane glycoprotein that plays a central role in platelet adhesion and aggregation. It is primarily expressed on platelets and megakaryocytes. Together with integrin beta 3 (ITGB3), ITGA2B forms the αIIbβ3 integrin complex (also known as GPIIb/IIIa), which is the most abundant integrin on the surface of platelets and is crucial for blood clot formation (hemostasis). This receptor mediates platelet aggregation by binding to fibrinogen, von Willebrand factor (vWF), fibronectin, and other adhesive proteins during platelet activation. When platelets are stimulated, the αIIbβ3 complex undergoes a conformational change that allows it to bind its ligands and mediate platelet-platelet interactions.
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