Integrin Alpha IIb / CD41 (ITGA2B) Antibody (FITC)
429€ (100 µg)
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935106861
info@markelab.com
name
Integrin Alpha IIb / CD41 (ITGA2B) Antibody (FITC)
category
Primary Antibodies
provider
Abbexa
reference
abx413901
tested applications
FCM
Description
Integrin Alpha-IIb (CD41) Antibody (FITC) is a Rat Monoclonal antibody against Integrin Alpha-IIb (CD41).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Integrin Alpha IIb / CD41 (ITGA2B) |
| Host | Rat |
| Reactivity | Mouse |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | FITC |
| Isotype | IgG1 |
| Purification | Purified |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | FCM |
| Buffer | PBS, 1% BSA. Contains sodium azide. |
| Availability | Shipped within 3-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9QUM0 |
| Alias | GT,GT1,GTA,CD41,GP2B,HPA3,CD41B,GPIIb,BDPLT2,BDPLT16,PPP1R93,Integrin alpha-Iib,GPalpha IIb (GPIIb),Platelet membrane glycoprotein IIb |
| Background | Antibody anti-ITGA2B |
| Status | RUO |
| Note | Concentration: 0.1 mg/ml - |
Descripción
ITGA2B, also known as integrin alpha 2b or CD41, is a transmembrane glycoprotein that plays a central role in platelet adhesion and aggregation. It is primarily expressed on platelets and megakaryocytes. Together with integrin beta 3 (ITGB3), ITGA2B forms the αIIbβ3 integrin complex (also known as GPIIb/IIIa), which is the most abundant integrin on the surface of platelets and is crucial for blood clot formation (hemostasis). This receptor mediates platelet aggregation by binding to fibrinogen, von Willebrand factor (vWF), fibronectin, and other adhesive proteins during platelet activation. When platelets are stimulated, the αIIbβ3 complex undergoes a conformational change that allows it to bind its ligands and mediate platelet-platelet interactions.
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