Integrin alpha-3 Antibody
364€ (100 µg)
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935106861
info@markelab.com
name
Integrin alpha-3 Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx234345
tested applications
ELISA, WB
Description
Integrin alpha-3 Antibody is a Mouse Monoclonal against Integrin alpha-3.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Integrin alpha-3 |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG2a |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by Protein A and Protein G affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P26006 |
| Gene ID | 3675 |
| OMIM | 605025 |
| Alias | JEB7,VL3A,CD49C,FRP-2,GAPB3,ILNEB,MSK18,VCA-2,VLA3a,GAP-B3,Integrin alpha-3,CD49 antigen-like family member C,Galactoprotein B3,VLA-3 subunit alpha |
| Background | Antibody anti-ITGA3 |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
Integrin subunit alpha 3 (ITGA3) is part of the integrin family, which are heterodimeric transmembrane receptors crucial for mediating interactions between cells and the extracellular matrix (ECM). Integrins are essential for cell adhesion, migration, and signal transduction, contributing to various biological processes such as tissue repair, immune response, and embryonic development. ITGA3 pairs with integrin beta 1 (ITGB1) to form the α3β1 integrin, which serves as a receptor for laminin, fibronectin, and other ECM components, playing a vital role in cell adhesion and migration. ITGA3 is encoded by the ITGA3 gene, located on chromosome 17q21.33. The expression of ITGA3 is widespread, particularly in tissues such as epithelial cells, endothelial cells, and neurons. The α3β1 integrin is involved in important physiological processes like embryogenesis, angiogenesis, and wound healing, as well as in tumor metastasis and invasion in pathological conditions. In cancer biology, ITGA3 is often associated with tumor progression and can influence cellular invasiveness.
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