Integrin Alpha 2 (ITGa2) Antibody
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Description
Polyclonal Antibody to Integrin Alpha 2 (ITGa2).
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Integrin Alpha 2 (ITGa2) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1-5 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P17301 |
| Alias | BR,GPIa,CD49B,HPA-5,VLA-2,VLAA2,CD49 antigen-like family member B,Collagen receptor,Platelet membrane glycoprotein Ia,VLA-2 subunit alpha |
| Background | Antibody anti-ITGA2 |
| Status | RUO |
Descripción
Integrin subunit alpha 2 (ITGA2) is part of the integrin family, a group of heterodimeric transmembrane receptors composed of alpha and beta subunits. These receptors are critical for cell-ECM (extracellular matrix) interactions and cell-cell adhesion, with a wide variety of biological processes such as cell migration, proliferation, differentiation, and signal transduction. ITGA2 forms a dimer with integrin beta 1 (ITGB1), giving rise to the α2β1 integrin, also known as the collagen receptor. This receptor specifically binds to collagen and laminin in the ECM, playing a crucial role in mediating cellular adhesion to collagen fibers in tissues. The ITGA2 gene, located on chromosome 5q11.2, encodes the alpha 2 integrin subunit. ITGA2 is expressed in various cell types, including epithelial cells, platelets, fibroblasts, and immune cells. Its activity is essential in processes such as wound healing, angiogenesis, hemostasis, and the maintenance of tissue integrity. Additionally, α2β1 integrin has significant involvement in tumor biology, where it modulates cancer cell invasion and metastasis by interacting with the ECM.
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