Inducible T-Cell Costimulator (ICOS) Antibody (APC)
637€ (100 tests)
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935106861
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name
Inducible T-Cell Costimulator (ICOS) Antibody (APC)
category
Primary Antibodies
provider
Abbexa
reference
abx270585
tested applications
FCM
Description
Inducible T-Cell Co Stimulator (ICOS) Antibody (APC) is a Rabbit Polyclonal Antibody conjugated to APC against Inducible T-Cell Co Stimulator (ICOS) for use in flow cytometry.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Inducible T-Cell Costimulator (ICOS) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | FCM: 1-5 µl/106 cells. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | APC |
| Isotype | IgG |
| Purification | Purified by antigen-specific affinity chromatography. |
| Size 1 | 100 tests |
| Size 2 | 200 tests |
| Size 3 | 500 tests |
| Form | Liquid |
| Tested Applications | FCM |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at 2°C to 8°C upon receipt. Avoid exposure to light. |
| Dry Ice | No |
| Alias | Activation-inducible lymphocyte immunomediatory molecule,AILIM,CD278,CVID1 |
| Background | Antibody anti-ICOS |
| Status | RUO |
Descripción
Inducible T-cell costimulator (ICOS), a member of the CD28 family of costimulatory receptors, is expressed on activated T cells and plays a crucial role in modulating immune responses. ICOS, encoded by the ICOS gene, provides an essential costimulatory signal that promotes T cell activation, differentiation, and cytokine production. Upon activation by its ligand, ICOS ligand (ICOSLG or CD275), which is found on antigen-presenting cells (APCs) like B cells, dendritic cells, and macrophages, ICOS triggers intracellular signaling pathways that enhance T-cell effector functions. ICOS is crucial for both humoral and cell-mediated immunity. It enhances T-helper cell responses, particularly in the germinal centers of lymphoid tissues, where it influences B cell differentiation and supports antibody production. ICOS signaling also helps maintain the balance between effector and regulatory T cells, impacting inflammation control and immune tolerance. The ICOS/ICOSLG pathway is vital in the immune system's ability to fight infection and respond to vaccination, as well as in controlling immune tolerance to prevent autoimmune diseases.
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