Inducible T-Cell Costimulator (ICOS) Antibody
442€ (200 µl)
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935106861
info@markelab.com
name
Inducible T-Cell Costimulator (ICOS) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx431979
tested applications
P-ELISA, IHC
Description
ICOS Antibody is a Goat Polyclonal antibody against ICOS.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Inducible T-Cell Costimulator (ICOS) Immunogen: abx615963 - Internal region: KGGQILCDLTKTKGS |
| Host | Goat |
| Reactivity | Human |
| Assay Type | Concentration: 0.5 mg/ml |
| Recommended Dilution | P-ELISA: 1/32000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, IHC |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 29851, 54167 |
| NCBI Accession | NP_036224.1 |
| Alias | Activation-inducible lymphocyte immunomediatory molecule,AILIM,CD278,CVID1 |
| Background | Antibody anti-ICOS |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
Inducible T-cell costimulator (ICOS), a member of the CD28 family of costimulatory receptors, is expressed on activated T cells and plays a crucial role in modulating immune responses. ICOS, encoded by the ICOS gene, provides an essential costimulatory signal that promotes T cell activation, differentiation, and cytokine production. Upon activation by its ligand, ICOS ligand (ICOSLG or CD275), which is found on antigen-presenting cells (APCs) like B cells, dendritic cells, and macrophages, ICOS triggers intracellular signaling pathways that enhance T-cell effector functions. ICOS is crucial for both humoral and cell-mediated immunity. It enhances T-helper cell responses, particularly in the germinal centers of lymphoid tissues, where it influences B cell differentiation and supports antibody production. ICOS signaling also helps maintain the balance between effector and regulatory T cells, impacting inflammation control and immune tolerance. The ICOS/ICOSLG pathway is vital in the immune system's ability to fight infection and respond to vaccination, as well as in controlling immune tolerance to prevent autoimmune diseases.
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