Inducible T-Cell Co Stimulator Ligand (ICOSLG) Antibody (PE)
585€ (100 tests)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Inducible T-Cell Co Stimulator Ligand (ICOSLG) Antibody (PE)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx270833
Tested Applications
FCM
Description
Inducible T-Cell Co Stimulator Ligand (ICOSLG) Antibody (PE) is a Rabbit Polyclonal Antibody conjugated to PE against Inducible T-Cell Co Stimulator Ligand (ICOSLG) for use in flow cytometry.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Inducible T-Cell Co Stimulator Ligand (ICOSLG) |
| Host | Rabbit |
| Reactivity | Human |
| Detection Method | Laser Line: 550 Excitation/Emission: 565/575 |
| Recommended Dilution | FCM: 1-5 µl/106 cells. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | PE |
| Isotype | IgG |
| Purification | Purified by antigen-specific affinity chromatography. |
| Size 1 | 100 tests |
| Size 2 | 200 tests |
| Size 3 | 500 tests |
| Form | Liquid |
| Tested Applications | FCM |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Please enquire. |
| Storage | Aliquot and store at 2°C to 8°C upon receipt. Avoid exposure to light. |
| Dry Ice | No |
| Alias | ICOS ligand, B7RP1,CD275,ICOSL,LICOS,B7RP-1,ICOS-L,IMD119,B7 homolog 2 |
| Background | Antibody anti-ICOSLG |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Inducible T-cell costimulator ligand (ICOSLG), also known as B7-H2 or CD275, is a critical immunoregulatory protein in the B7 family that provides costimulatory signals to T cells. ICOSLG serves as a ligand for ICOS (Inducible T-cell Costimulator), a receptor expressed on activated T cells. Through its interaction with ICOS, ICOSLG plays an essential role in modulating adaptive immune responses, particularly influencing T-cell differentiation, proliferation, and the formation of memory T cells. This interaction is crucial for both protective immunity and immune tolerance, enabling the immune system to respond robustly to pathogens while preventing autoimmunity. ICOSLG is primarily expressed on antigen-presenting cells (APCs), such as B cells, dendritic cells (DCs), macrophages, and certain epithelial cells in mucosal tissues. Its expression is inducible and can be upregulated during inflammation or immune activation by signals from pro-inflammatory cytokines like interferon-gamma (IFN-γ). The ICOS/ICOSLG axis is especially important for the regulation of germinal center formation in lymphoid tissues, where it facilitates B cell differentiation and antibody production. ICOSLG is also implicated in the maintenance of regulatory T cells (Tregs) and T-helper 17 (Th17) cells, thereby contributing to immune homeostasis and controlling inflammation.
Productos relacionados
ICOS Ligand (ICOSLG) Antibody
ICOS Ligand (ICOSLG) Antibody is a Rabbit Polyclonal Antibody against ICOS Ligand (ICOSLG).…
Ver producto
Human Inducible T-Cell Co Stimulator Ligand (ICOSLG) Protein
Human Inducible T-Cell Co Stimulator Ligand (ICOSLG) protein is a recombinant protein expressed in E. coli.…
Ver producto
Inducible T-Cell Co Stimulator Ligand (ICOSLG) Antibody
Polyclonal Antibody to Inducible T-Cell Co Stimulator Ligand (ICOSLG).…
Ver producto