inBcl-2 Homologous Antagonist/killer (bak) Antibody
357.5€ (100 µg)
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Name
inBcl-2 Homologous Antagonist/killer (bak) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx038307
Tested Applications
ELISA, WB
Description
Rabbit Polyclonal against the bak protein.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: inBcl-2 Homologous Antagonist/killer (bak) Immunogen: A peptide corresponding to N termianl of human Bak protein. |
| Host | Rabbit |
| Reactivity | Human, Mouse |
| Assay Type | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Observed MW: 23 kDa |
| Purification | Purified by Protein A/G column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, WB |
| Buffer | Prior to lyophilization: 0.02% NaN3. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| NCBI Accession | NP_001179 |
| Alias | BAK,BAK-LIKE,BCL2L7,CDN1,Bcl-2 homologous antagonist/killer,Apoptosis regulator BAK,Bcl-2-like protein 7,Bcl2-L-7 |
| Background | Antibody anti-BAK1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
BCL2 antagonist/killer 1 (BAK1) is a pro-apoptotic member of the Bcl-2 family of proteins, which regulate cell death pathways and cellular survival BAK1 plays a critical role in mitochondrial-mediated apoptosis, where it promotes the release of cytochrome c from the mitochondria, triggering the activation of caspase enzymes that lead to programmed cell death It functions as a key mediator of apoptosis in response to cellular stress, DNA damage, and oncogenic signaling, making it essential for maintaining cellular homeostasis and preventing the accumulation of damaged cells BAK1's activation is tightly regulated by anti-apoptotic proteins like Bcl-2, and its dysregulation is commonly associated with cancer, where loss of BAK1 function allows tumor cells to evade apoptosis, promoting tumor growth and resistance to chemotherapy Studies have also linked BAK1 to neurodegenerative diseases, where its dysregulation may contribute to neuronal loss and dysfunction Additionally, BAK1 has been implicated in immune responses, where it regulates T-cell homeostasis and immune cell survival, underscoring its broader role in cellular death and immune regulation
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