Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1) Antibody
299€ (50 µl)
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Name
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx349953
Tested Applications
ELISA
Description
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1) Antibody is a Recombinant Human Monoclonal antibody for the detection of Human ROR1.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1) Immunogen: Recombinant Human ROR1 protein |
| Host | Human |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Expression | Recombinant |
| Purification | Purified by affinity chromatography. |
| Size 1 | 50 µl |
| Size 2 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q01973 |
| Gene ID | 4919 |
| OMIM | 602336 |
| Alias | NTRKR1,dJ537F10.1,Inactive tyrosine-protein kinase transmembrane receptor ROR1,Neurotrophic tyrosine kinase, receptor-related 1 |
| Background | Antibody anti-ROR1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
ROR1 (Receptor Tyrosine Kinase-Like Orphan Receptor 1) is a member of the receptor tyrosine kinase family, playing a pivotal role in embryonic development and cellular signaling. While minimally expressed in normal adult tissues, ROR1 is highly expressed in various cancers, including chronic lymphocytic leukemia and breast cancer, where it contributes to tumor progression, survival, and metastasis. This makes ROR1 a promising therapeutic target in oncology. The receptor participates in Wnt5a-mediated non-canonical Wnt signaling pathways, which regulate cell migration and cytoskeletal dynamics, critical processes during development and pathological states such as cancer. Its restricted expression pattern in normal tissues highlights its potential for targeted cancer therapies.
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