Importin Subunit Alpha-6 (KPNA5) Antibody
169€ (20 µl)
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Name
Importin Subunit Alpha-6 (KPNA5) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx320894
Tested Applications
ELISA, IHC
Description
KPNA5 Antibody is a Rabbit Polyclonal against KPNA5.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Importin Subunit Alpha-6 (KPNA5) Immunogen: Recombinant human Importin subunit alpha-6 protein (1-240AA). |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Antigen Affinity Chromatography. |
| Size 1 | 20 µl |
| Size 2 | 50 µl |
| Size 3 | 100 µl |
| Size 4 | 200 µl |
| Size 5 | 1 ml |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O15131 |
| Gene ID | 3841 |
| OMIM | 604545 |
| Alias | IPOA6,SRP6,Importin subunit alpha-6 |
| Background | Antibody anti-KPNA5 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
KPNA5, or importin-α6, functions as an adaptor protein mediating the nuclear import of cargo proteins containing classical nuclear localization signals (NLS). It forms a heterodimer with importin-β to translocate proteins across the nuclear pore complex (NPC) in an energy-dependent manner. KPNA5 is predominantly expressed in the brain, testes, and immune cells, suggesting specialized roles in neuronal function, germ cell development, and immune regulation. It regulates nuclear import of transcription factors and signaling proteins involved in cell differentiation, stress responses, and viral replication. KPNA5 is implicated in neurodevelopmental disorders and cancers, where it modulates nuclear transport of growth and survival regulators. Functional studies demonstrate its critical role in maintaining nuclear transport specificity and cellular homeostasis during development and disease progression.
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