Immunoglobulin Superfamily Member 9 (IGSF9) Antibody (Biotin)

Background

IGSF9 is a transmembrane protein belonging to the immunoglobulin superfamily, predominantly expressed in the nervous system. It features multiple immunoglobulin (Ig)-like domains and fibronectin type III domains, which facilitate its role in cell adhesion and synaptic organization. IGSF9 is localized to excitatory synapses, where it contributes to the formation and stabilization of neuronal connections. Functionally, it is involved in regulating synaptic plasticity, neuronal communication, and memory formation. Dysregulation of IGSF9 is associated with neurodevelopmental and psychiatric disorders, including autism spectrum disorders (ASD) and intellectual disabilities, where impaired synaptic connectivity is a hallmark. Its role in maintaining neural circuits and supporting cognitive processes highlights its importance in brain function and disease.