IL13 109 a.a. Protein

Product specifications

Proteins and Peptides

IL13 109 a.a.

Rat

Unconjugated

Recombinant

> 95% (SDS-PAGE)

2 µg

10 µg

1 mg

Lyophilized

SDS-PAGE

Shipped within 5-10 working days.

No

P42203

P600,IL-13,NC30

Protein IL13

RUO

This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

Interleukin 13 (IL13) is a cytokine primarily involved in the regulation of immune responses, particularly those associated with allergies, asthma, and parasitic infections. IL-13 is produced mainly by T-helper type 2 (Th2) cells, a subset of CD4+ T cells that are central to immune responses against extracellular pathogens, especially helminths, and in promoting allergic reactions. Other cell types, including natural killer (NK) cells, mast cells, basophils, eosinophils, and innate lymphoid cells (ILC2), also secrete IL-13. IL-13 plays a critical role in coordinating allergic inflammation by promoting the production of IgE by B cells, mucus secretion in the lungs, and tissue remodeling, all of which are hallmarks of allergic diseases such as asthma. Importantly, IL-13 shares some overlapping functions with IL-4, another Th2 cytokine, due to the fact that both cytokines signal through a shared receptor subunit, the IL-4 receptor alpha (IL-4Rα). Despite this overlap, IL-13 also exerts unique effects, particularly in tissue fibrosis and remodeling, where it is a key driver.

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