Hypermethylated In Cancer 1 Protein (HIC1) Peptide

Product Graph
175.5€ (100 µg)

Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.

935106861
info@markelab.com
name
Hypermethylated In Cancer 1 Protein (HIC1) Peptide
category
Proteins and Peptides
provider
Abbexa
reference
abx616881
tested applications
P-ELISA

Description

Hypermethylated In Cancer 1 Protein (HIC1) Peptide is a synthetic peptide.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Proteins and Peptides
Immunogen Target
Hypermethylated In Cancer 1 Protein (HIC1)
Host
Synthetic
Recommended Dilution
BL (predicted): 0.5 mg/ml. Optimal dilutions/concentrations should be determined by the end user.
Conjugation
Unconjugated
Observed MW
Sequence Fragment: Internal region, 193-204 AA: NTHCAELYASGP
Size 1
100 µg
Form
Lyophilized Reconstitute in deionized water.
Tested Applications
P-ELISA
Buffer
Prior to lyophilization: Deionized water.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
Gene ID
3090, 15248, 303310
NCBI Accession
NP_006488.2, NP_001091672.1
Background
Protein HIC1
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

Related Products

FNab03857

HIC1 antibody

Transcriptional repressor. Recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. May act as a tumor suppressor. May be involved in development of head, face, limbs and ventral body wall. Involved in down-regulation of SIRT1 and thereby is involved in regulation of p53/TP53-dependent apoptotic DNA-damage responses. The specific target gene promoter association seems to be depend on corepressors, such as CTBP1 or CTBP2 and MTA1. The regulation of SIRT1 transcription in response to nutrient deprivation seems to involve CTBP1. In cooperation with MTA1(indicative for an association with the NuRD complex) represses transcription from CCND1/cyclin-D1 and CDKN1C/p57Kip2 specifically in quiescent cells. Involved in regulation of the Wnt signaling pathway probably by association with TCF7L2 and preventing TCF7L2 and CTNNB1 association with promoters of TCF-responsive genes. Seems to repress transcription from E2F1 and ATOH1 which involves ARID1A, indicative for the participation of a distinct SWI/SNF-type chromatin-remodeling complex. Probably represses transcription from ACKR3, FGFBP1 and EFNA1.

Ver Producto
abx124332

Hypermethylated In Cancer 1 Protein (HIC1) Antibody

HIC1 Antibody is a Rabbit Polyclonal Antibody against HIC1.

Ver Producto
abx233857

Hypermethylated In Cancer 1 Protein (HIC1) Antibody

HIC1 Antibody is a Rabbit Polyclonal against HIC1.

Ver Producto