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Hyaluronidase-2 (HYAL2) Antibody
proveedor
Abbexareference
abx025876Tested Applications
ELISA, WB, IHC, FCMreactivity
Humanstatus
RUOclonality
PolyclonalDescripción
This gene encodes a weak acid-active hyaluronidase. The encoded protein is similar in structure to other more active hyaluronidases. Hyaluronidases degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan and fragments of hyaluronan are thought to be involved in cell proliferation, migration and differentiation. Although it was previously thought to be a lysosomal hyaluronidase that is active at a pH below 4, the encoded protein is likely a GPI-anchored cell surface protein. This hyaluronidase serves as a receptor for the oncogenic virus Jaagsiekte sheep retrovirus. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. This gene encodes two alternatively spliced transcript variants which differ only in the 5' UTR.
Background
Hyaluronidase PH-20 is an enzyme encoded by the SPAM1 gene in humans. It is a member of the hyaluronidase family , which have the capacity degrade hyaluronic acid—a major structural proteoglycan found in extracellular matrices and basement membranes. The human genome contains six genes related to hyaluronidases, with three of them (HYAL1, HYAL2, and HYAL3) clustered on chromosome 3, and the other three (HYAL4, SPAM1, and HYALP1) clustered on chromosome 7. The extensive homology between these six hyaluronidase genes suggests an ancient gene duplication event that occurred before the emergence of modern mammals. Hyaluronidase PH-20 plays a role in various physiological processes, including sperm function and fertilization, due to its ability to modify the extracellular matrix by degrading hyaluronic acid. Aliases: HYA1; HYAL PH-20; HYAL PH20; Hyal-PH20; HYAL1; HYAL3; HYAL5; HYALP_HUMAN; Hyaluronidase PH-20; Hyaluronoglucosaminidase PH-20; MGC26532; PH-20 Hyaluronidase; PH20; PH20 Hyaluronidase; SPAG15; SPAM-1; SPAM1; Sperm adhesion molecule 1; Sperm surface protein
Background
La hialuronidasa PH-20 es una enzima codificada por el gen SPAM1 en humanos. Es miembro de la familia de las hialuronidasas, que tienen la capacidad de degradar el ácido hialurónico, un proteoglicano estructural importante que se encuentra en las matrices extracelulares y las membranas basales. El genoma humano contiene seis genes relacionados con las hialuronidasas, tres de ellos (HYAL1, HYAL2 y HYAL3) agrupados en el cromosoma 3, y los otros tres (HYAL4, SPAM1 y HYALP1) agrupados en el cromosoma 7. La extensa homología entre estos seis genes de hialuronidasa sugieren un evento de duplicación de genes antiguo que ocurrió antes de la aparición de los mamíferos modernos. La hialuronidasa PH-20 desempeña un papel en diversos procesos fisiológicos, incluida la función de los espermatozoides y la fertilización, debido a su capacidad para modificar la matriz extracelular degradando el ácido hialurónico. Alias: HYA1; HIAL PH-20; HIAL PH20; hial-PH20; HIAL1; HIAL3; HIAL5; HYALP_HUMAN; Hialuronidasa PH-20; hialuronoglucosaminidasa PH-20; MGC26532; PH-20 Hialuronidasa; PH20; PH20 Hialuronidasa; SPAG15; SPAM-1; SPAM1; Molécula de adhesión de esperma 1; Proteína de la superficie del esperma
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Human
immunogen target
Hyaluronidase-2 (HYAL2)
host
Rabbit
conjugation
Unconjugated
form
Liquid
tested applications
ELISA, WB, IHC, FCM
purification
Purified through a protein A column, followed by peptide affinity purification.
buffer
PBS containing 0.09% sodium azide.
size 1
80 µl
size 2
400 µl
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
HYAL2
dry ice
No
availability
Shipped within 5-10 working days.
uniprot id
note
This product is for research use only.
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