Hyaluronan Mediated Motility Receptor (HMMR) Antibody (HRP)
169€ (20 µg)
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935106861
info@markelab.com
name
Hyaluronan Mediated Motility Receptor (HMMR) Antibody (HRP)
category
Primary Antibodies
provider
Abbexa
reference
abx336069
tested applications
ELISA
Description
HMMR Antibody (HRP) is a Rabbit Polyclonal against HMMR.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Hyaluronan Mediated Motility Receptor (HMMR) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | HRP |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O75330 |
| Gene ID | 3161 |
| Alias | CD168,IHABP,RHAMM,Intracellular hyaluronic acid-binding protein,Receptor for hyaluronan-mediated motility |
| Background | Antibody anti-HMMR |
| Status | RUO |
Descripción
The hyaluronan-mediated motility receptor (HMMR), also known as RHAMM (Receptor for Hyaluronan-Mediated Motility), is a protein encoded by the HMMR gene in humans. Originally identified in studies focusing on cancer cell motility, HMMR functions as a receptor for hyaluronan (HA), a component of the extracellular matrix (ECM) involved in tissue hydration, structural integrity, and cellular communication. HMMR has attracted significant scientific interest due to its roles in cellular adhesion, proliferation, migration, and wound healing. Its expression is often upregulated in cancer cells, contributing to increased cell motility and invasiveness, making it a focal point in oncology research. HMMR functions not only as a surface receptor but also intracellularly, interacting with various signaling pathways and microtubule networks, which influences cell division and chromosomal stability. Given its involvement in pathways like RAS and ERK and its interaction with the mitotic spindle, HMMR is critical in cell cycle regulation and tissue morphogenesis. Dysregulated HMMR expression has been associated with cancer progression, inflammatory diseases, and even osteoarthritis, placing it at the intersection of various physiological and pathological processes.
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