Human WT1 Associated Protein (WTAP) Protein

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1235€ (100 µg)

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935106861
info@markelab.com
name
Human WT1 Associated Protein (WTAP) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx693166
tested applications
SDS-PAGE

Description

Human WTAP Protein is a recombinant protein from Human produced in E. coli. A DNA sequence encoding the human WTAP isoform 2 (Q15007-2) (Met 1-Arg 151) was fused with the GST tag at the N-terminus.

Documents del producto

Instrucciones
Data sheet
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Product specifications

Category
Proteins and Peptides
Immunogen Target
WTAP
Host
E. coli
Origin
Human
Observed MW
Molecular Weight: 45 kDa

Sequence Fragment: Met1-Arg151

Tag: N-terminal GST tag

Validity: The validity for this protein is 12 months.
Expression
Recombinant
Purity
> 90% (SDS-PAGE)
Size 1
100 µg
Tested Applications
SDS-PAGE
Buffer
Lyophilized from sterile 20mM Tris, 0.15M NaCl, 0.5mM GSH, pH 8.0.
Availability
Shipped within 5-15 working days.
Storage
Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
Q15007-2
Background
Protein WTAP
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

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Regulatory subunit of the WMM N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine(m6A) methylation of some adenosine residues of some mRNAs and plays a role in the efficiency of mRNA splicing, processing and mRNA stability. Required for accumulation of METTL3 and METTL14 to nuclear speckle(PubMed:24316715, PubMed:24407421, PubMed:24981863). Acts as a mRNA splicing regulator(PubMed:12444081). Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability(PubMed:17088532). Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes(PubMed:17095724).

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