Human Pre-mRNA-Splicing Regulator Wtap (WTAP) Protein

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1235€ (100 µg)

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935106861
info@markelab.com
name
Human Pre-mRNA-Splicing Regulator Wtap (WTAP) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx693166
tested applications
SDS-PAGE

Description

Pre-mRNA-Splicing Regulator Wtap (WTAP) protein is a recombinant Human protein expressed in E. coli.

Documents del producto

Instrucciones
Data sheet
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Product specifications

Category
Proteins and Peptides
Immunogen Target
Pre-mRNA-Splicing Regulator Wtap (WTAP)
Host
E. coli
Assay Type
Activity: Not tested
Sequence Fragment: Met1-Arg151
Tag: N-terminal GST tag
Origin
Human
Observed MW
45 kDa
Expression
Recombinant
Purity
> 90% (SDS-PAGE)
Size 1
100 µg
Form
Lyophilized
Tested Applications
SDS-PAGE
Buffer
Prior to lyophilization: Sterile 20 mM Tris, 0.15M NaCl, 0.5 mM GSH, pH 8.0.
Availability
Shipped within 5-15 working days.
Storage
Storage: Store lyophilized between -20 °C and -80°C.
Stability: Stable when stored reconstituted at 2-8°C for up to 1 week. Reconstituted aliquots are stable at -20°C for up to 3 months.
Shelf Life: 12 months.
Dry Ice
No
UniProt ID
Q15007-2
Background
Protein WTAP
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.

Descripción

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Regulatory subunit of the WMM N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine(m6A) methylation of some adenosine residues of some mRNAs and plays a role in the efficiency of mRNA splicing, processing and mRNA stability. Required for accumulation of METTL3 and METTL14 to nuclear speckle(PubMed:24316715, PubMed:24407421, PubMed:24981863). Acts as a mRNA splicing regulator(PubMed:12444081). Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability(PubMed:17088532). Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes(PubMed:17095724).
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Regulatory subunit of the WMM N6-methyltransferase complex, a multiprotein complex that mediates N6-methyladenosine(m6A) methylation of some adenosine residues of some mRNAs and plays a role in the efficiency of mRNA splicing, processing and mRNA stability. Required for accumulation of METTL3 and METTL14 to nuclear speckle(PubMed:24316715, PubMed:24407421, PubMed:24981863). Acts as a mRNA splicing regulator(PubMed:12444081). Regulates G2/M cell-cycle transition by binding to the 3' UTR of CCNA2, which enhances its stability(PubMed:17088532). Impairs WT1 DNA-binding ability and inhibits expression of WT1 target genes(PubMed:17095724).
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