Human WAP, kazal, immunoglobulin, kunitz and NTR domain-containing protein 2 (WFIKKN2) Protein
1118€ (50 µg)
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Name
Human WAP, kazal, immunoglobulin, kunitz and NTR domain-containing protein 2 (WFIKKN2) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx692161
Tested Applications
SDS-PAGE
Description
Human WFIKKN2 Protein is a recombinant protein from Human produced in HEK293 Cells. A DNA sequence encoding the human WFIKKN2 (NP_783165.1) extracellular domain (Met 1-His 576) was expressed, with a polyhistidine tag at the C-terminus.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | WFIKKN2 |
| Host | HEK293 cells |
| Assay Type | Activity: Not tested Sequence Fragment: Met1-His576 Tag: C-terminal His tag |
| Origin | Human |
| Observed MW | 61.4 kDa |
| Expression | Recombinant |
| Purity | > 96% (SDS-PAGE) |
| Size 1 | 50 µg |
| Form | Lyophilized |
| Tested Applications | SDS-PAGE |
| Buffer | Lyophilized from sterile PBS, pH 7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Storage: Store lyophilized between -20 °C and -80°C. Stability: Stable when stored reconstituted at 2-8°C for up to 1 week. Reconstituted aliquots are stable at -20°C for up to 3 months. Shelf Life: 12 months. |
| Dry Ice | No |
| NCBI Accession | NP_783165.1 |
| Alias | GASP-1,WFDC20B,hGASP-1,WFIKKNRP,WFIKKN-related protein,Growth and differentiation factor-associated serum protein 1,GASP-1,hGASP-1 |
| Background | Protein WFIKKN2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. Endotoxin Level: < 1.0 EU per µg (LAL method). |
Background
WAP follistatin/kazal immunoglobulin kunitz and netrin domain containing 2 (WFIKKN2) shares structural and functional similarities with WFIKKN1, including its role as a protease inhibitor and regulator of extracellular matrix dynamics. It is particularly known for its interaction with growth differentiation factors such as GDF8 (myostatin) and GDF11, inhibiting their activity and contributing to the regulation of muscle and skeletal growth. WFIKKN2 is expressed in various tissues, including the liver, kidney, and skeletal muscle, and plays a crucial role in maintaining tissue homeostasis by modulating protease activity during processes like inflammation, repair, and cellular migration. In cancer biology, WFIKKN2 has been implicated in controlling tumor progression and metastasis by influencing proteolytic activity in the tumor microenvironment. Additionally, WFIKKN2 has potential therapeutic applications in metabolic and degenerative disorders due to its regulatory effects on signaling pathways associated with growth differentiation factors. The interplay between WFIKKN2 and other extracellular molecules continues to be a focus of study, with particular interest in its potential to serve as a biomarker or therapeutic target in diseases characterized by abnormal proteolysis or tissue remodeling.
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