Human Vitamin D3 Receptor (VDR) Protein
1222€ (20 µg)
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name
Human Vitamin D3 Receptor (VDR) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx600076
tested applications
SDS-PAGE
Description
Human Vitamin D3 Receptor (VDR) Protein is a recombinant Human protein expressed in E. coli
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Vitamin D3 Receptor (VDR) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Sequence Fragment: Full length, 1-427 AA. Tag: The tag will be determined during the production process. Validity: 6 months in liquid form, or 12 months in lyophilized form. |
| Expression | Recombinant |
| Purity | > 85% (SDS-PAGE) |
| Size 1 | 20 µg |
| Size 2 | 100 µg |
| Size 3 | 1 mg |
| Form | Liquid |
| Tested Applications | SDS-PAGE |
| Buffer | Tris-based buffer, 50% glycerol. |
| Availability | Shipped within 2-4 months. |
| Storage | Store at -20 °C for up to 6 months in liquid form, or for up to 12 months in lyophilized form. Aliquots can be stored at 4 °C for up to one week. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P11473 |
| Alias | NR1I1,PPP1R163,Vitamin D3 receptor,1,25-dihydroxyvitamin D3 receptor,Nuclear receptor subfamily 1 group I member 1 |
| Background | Protein VDR |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Vitamin D receptor (VDR) is a nuclear receptor that mediates the effects of vitamin D, a crucial nutrient involved in calcium and phosphate homeostasis, bone health, immune function, and cellular growth VDR is activated upon binding to the active form of vitamin D, calcitriol, which allows it to regulate gene expression by binding to vitamin D response elements (VDREs) in target genes VDR is involved in regulating calcium absorption in the intestine, bone mineralization, and the modulation of immune responses, particularly in regulating inflammation and the function of T cells It also plays a role in the prevention of certain cancers, cardiovascular diseases, and autoimmune disorders Dysregulation of VDR activity has been linked to diseases such as osteoporosis, rickets, cardiovascular disease, and cancer In addition, VDR is a target for therapies aimed at managing conditions related to vitamin D deficiency, autoimmune diseases, and bone disorders
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